Rosalie Martinez arrived in Port Charles as the personal nurse of Nina Clay, fresh out of her 20-year coma. It was soon revealed that Rosalie was aware that Nina could walk and was with Nina to help her commit revenge on a number of residents, including Dr. Silas Clay, Sam Morgan, Ava Jerome, and Kiki Jerome. She disliked Silas for how he treated Nina, and didn't hide her feelings about him from anyone.

While Rosalie was in the park one day, she threw her cell phone in frustration and hit Morgan Corinthos in the head. The two talked about their father issues and exchanged numbers. When Nina asked Rosalie to use her womanly charms to seduce Michael Corinthos away from Kiki, Rosalie resisted because of her feelings for his brother. Nina insisted so Rosalie met up with Morgan for a double-date with Michael and planted seeds with Michael that something could still be going on between Morgan and Kiki.

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